Drug General Information
Drug ID
D0VI2A
Former ID
DIB019381
Drug Name
compound 25
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529206]
Structure
Download
2D MOL
Formula
C25H37N3O7S
InChI
InChI=1S/C25H37N3O7S/c1-18-5-2-3-6-20(18)19-9-13-28(14-10-19)36(33,34)17-25(23(30)26-32)11-15-27(16-12-25)24(31)35-22-8-4-7-21(22)29/h2-3,5-6,19,21-22,29,32H,4,7-17H2,1H3,(H,26,30)
InChIKey
JRYQAIVHIZIBOQ-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mRNA of Human ADAM10 Target Info Inhibitor [529206]
KEGG Pathway Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway RANKL Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Pathway Interaction Database Notch signaling pathway
Presenilin action in Notch and Wnt signaling
Posttranslational regulation of adherens junction stability and dissassembly
Reactome Collagen degradation
Degradation of the extracellular matrix
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7
M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
WikiPathways Hypertrophy Model
Copper homeostasis
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH2
Alzheimers Disease
Signaling by EGFR
References
Ref 529206Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett. 2008 Jan 15;18(2):560-4. Epub 2007 Nov28.
Ref 529206Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett. 2008 Jan 15;18(2):560-4. Epub 2007 Nov28.

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