Drug Information

Drug General Information
Drug ID
D09KLR
Former ID
DAP000182
Drug Name
Alendronate
Synonyms
Arendal; Fosamax; ALENDRONATE SODIUM; ALENDRONIC ACID; Acide alendronique; Acido alendronico; Acidum alendronicum; MK 217; Acide alendronique [INN-French]; Acido alendronico [INN-Spanish]; Acidum alendronicum [INN-Latin]; Alendronic acid (INN); Alendronic acid [INN:BAN]; Bisphosphonate, 65; Fosamax (TN); MK-217; Phosphonic acid, (4-amino-1-hydroxybutylidene)bis; (4-Amino-1-hydroxybutylidene)bisphosphonic acid; (4-Amino-1-hydroxybutylidene)diphosphonic acid; (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid; (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid); 4-Amino-1-hydroxybutane-1,1-diphosphonate; 4-Amino-1-hydroxybutane-1,1-diphosphonic Acid; 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid); 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
Drug Type
Small molecular drug
Indication Osteoporosis; Paget's disease [ICD9: 731.0, 733.0; ICD10:M80-M81, M88] Approved [536664], [540141]
Therapeutic Class
Bone Density Conservation Agents
Company
Teva Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C4H13NO7P2
Canonical SMILES
C(P(=O)(O)[O-])(P(=O)(O)O)(O)CCCN.[Na+].O.O.O
InChI
InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12)
InChIKey
OGSPWJRAVKPPFI-UHFFFAOYSA-N
CAS Number
CAS 66376-36-1
PubChem Compound ID
2088
PubChem Substance ID
9954, 649130, 7344414, 7978659, 8151420, 10318378, 15196679, 26612802, 26750071, 29215185, 29215186, 29221268, 46393653, 46507199, 47291221, 48110541, 48415528, 50007414, 50659878, 51091458, 53790851, 53801179, 56374454, 57321131, 87560297, 93166338, 103228757, 104299568, 105562999, 118402569, 125645927, 126524218, 126685342, 127330008, 127330009, 127330010, 127330011, 127330012, 127330186, 127330187, 127330188, 127330189, 128806596, 131322978, 131349593, 134337502, 135007310, 135366402, 135649795, 136991069
ChEBI ID
ChEBI:2567
SuperDrug ATC ID
M05BA04
SuperDrug CAS ID
cas=066376361
Target and Pathway
Target(s) Farnesyl pyrophosphate synthase Target Info Modulator [556264]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
References
Ref 536664Osteonecrosis of the jaw. South Med J. 2008 Feb;101(2):160-5.
Ref 540141(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3141).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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