Drug Information

Drug General Information
Drug ID
D0T8OD
Former ID
DNC000449
Drug Name
Clobenpropit
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538735]
Structure
Download
2D MOL

3D MOL
Formula
C14H17ClN4S
InChI
InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
InChIKey
UCAIEVHKDLMIFL-UHFFFAOYSA-N
CAS Number
CAS 145231-45-4
PubChem Compound ID
2790
PubChem Substance ID
5527870, 7978963, 11113684, 14825609, 26751870, 29221945, 46387016, 47285823, 47880062, 49846355, 50064442, 52669832, 53786950, 56189213, 57321461, 85209029, 85217202, 85787566, 92308565, 96024155, 103122768, 103177239, 103948188, 104301619, 117462906, 124659143, 125335692, 129346746, 134339871, 135066703, 135610794, 135650109, 137185855, 142667102, 144089087, 162022319, 162220959, 172080540, 179148467, 179293846, 184591678, 198948919, 226432891, 233838136, 252347508, 252431987
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [537147], [537280]
Histamine H3 receptor Target Info Antagonist [534934], [536039]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
GPCRs, Class A Rhodopsin-like
References
Ref 538735(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1223).
Ref 534934Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol. 1999 Sep-Oct;13(5):391-9.
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.
Ref 537147The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol. 2009 Mar;123(3):619-25.
Ref 537280Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. Bioorg Med Chem. 2009 Jun 1;17(11):3987-94. Epub 2009 Apr 11.

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