Drug General Information |
Drug ID |
D0A3OF
|
Former ID |
DCL000817
|
Drug Name |
GMC-283
|
Drug Type |
Small molecular drug
|
Indication |
Schizophrenia [ICD9: 295; ICD10:F20]
|
Terminated |
[1]
|
Company |
Merck KGaA
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C19H18F3N3O4S
|
Canonical SMILES |
CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)OS(=O)(=O)C(F)<br />(F)F
|
InChI |
1S/C19H18F3N3O4S/c1-24-8-10-25(11-9-24)18-14-12-13(29-30(26,27)19(20,21)22)6-7-16(14)28-17-5-3-2-4-15(17)23-18/h2-7,12H,8-11H2,1H3
|
InChIKey |
DQNCRNVCBHYBQP-UHFFFAOYSA-N
|
CAS Number |
CAS 183140-98-9
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PubChem Compound ID |
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PubChem Substance ID |
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Target and Pathway |
Target(s) |
D(1B) dopamine receptor |
Target Info |
Antagonist |
[1]
|
5-hydroxytryptamine 2A receptor |
Target Info |
Antagonist |
[1]
|
D(2) dopamine receptor |
Target Info |
Antagonist |
[1]
|
KEGG Pathway
|
Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04020:Calcium signaling pathway
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Gap junction
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholism
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PANTHER Pathway
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Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
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G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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Nicotine Activity on Dopaminergic Neurons
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References |
REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. |