| Drug General Information |
| Drug ID |
D0B1YM
|
| Former ID |
DNC010728
|
| Drug Name |
Gymnochrome E
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C36H26Br2O10
|
| Canonical SMILES |
CCCC(CC1=C(C(=C2C3=C1C4=C5C6=C3C7=C(C(=CC(=C7C2=O)O)O)C<br />8=C6C(=C(C=C8O)O)C(=O)C5=C(C(=C4CC(C)O)Br)O)O)Br)O
|
| InChI |
1S/C36H26Br2O10/c1-3-4-10(40)6-12-18-17-11(5-9(2)39)31(37)35(47)29-23(17)27-25-19(13(41)7-15(43)21(25)33(29)45)20-14(42)8-16(44)22-26(20)28(27)24(18)30(34(22)46)36(48)32(12)38/h7-10,39-44,47-48H,3-6H2,1-2H3/t9-,10+/m0/s1
|
| InChIKey |
FQXGDTNOEQJUMM-VHSXEESVSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histone deacetylase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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Cell cycle
|
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Notch signaling pathway
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Thyroid hormone signaling pathway
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Huntington's disease
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Amphetamine addiction
|
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Alcoholism
|
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Epstein-Barr virus infection
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Pathways in cancer
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Transcriptional misregulation in cancer
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Viral carcinogenesis
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MicroRNAs in cancer
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Chronic myeloid leukemia
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Wnt signaling pathway
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p53 pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Notch signaling pathway
|
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E2F transcription factor network
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Presenilin action in Notch and Wnt signaling
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Signaling events mediated by HDAC Class I
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Sumoylation by RanBP2 regulates transcriptional repression
|
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Regulation of Androgen receptor activity
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IL3-mediated signaling events
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Validated nuclear estrogen receptor alpha network
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Retinoic acid receptors-mediated signaling
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Hedgehog signaling events mediated by Gli proteins
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Regulation of nuclear beta catenin signaling and target gene transcription
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Validated targets of C-MYC transcriptional repression
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Regulation of retinoblastoma protein
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Notch-mediated HES/HEY network
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Reactome
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G0 and Early G1
|
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p75NTR negatively regulates cell cycle via SC1
|
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Formation of the beta-catenin:TCF transactivating complex
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NOTCH1 Intracellular Domain Regulates Transcription
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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HDACs deacetylate histones
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Deactivation of the beta-catenin transactivating complex
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NoRC negatively regulates rRNA expression
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RNA Polymerase I Transcription Initiation
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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SIDS Susceptibility Pathways
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Notch Signaling Pathway
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TGF beta Signaling Pathway
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IL-6 signaling pathway
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Apoptosis-related network due to altered Notch3 in ovarian cancer
|
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
|
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Notch Signaling Pathway
|
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Retinoblastoma (RB) in Cancer
|
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Neural Crest Differentiation
|
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TWEAK Signaling Pathway
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Integrated Breast Cancer Pathway
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Signalling by NGF
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
|
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Cell Cycle
|
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Androgen receptor signaling pathway
|
| References |
| REF 1 | J Nat Prod. 2010 Apr 23;73(4):712-5.Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. |
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