Drug Information

Drug General Information
Drug ID
D0X8ED
Former ID
DNC000294
Drug Name
Benserazide
Drug Type
Small molecular drug
Indication Discovery agent Phase 3 [468214], [521673]
Structure
Download
2D MOL

3D MOL
Formula
C10H15N3O5
InChI
InChI=1S/C10H15N3O5/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16/h1-2,6,12,14-17H,3-4,11H2,(H,13,18)
InChIKey
BNQDCRGUHNALGH-UHFFFAOYSA-N
CAS Number
CAS 188968-51-6
PubChem Compound ID
2327
PubChem Substance ID
4377832, 7978766, 8151557, 11335644, 11360883, 11362884, 11365446, 11368008, 11371504, 11373793, 11376170, 11461855, 11466966, 11468086, 11483956, 11486781, 11487956, 11490128, 11492062, 11493884, 15094804, 17397237, 29221497, 47365134, 47662229, 47736422, 47810707, 48035061, 48035062, 48184949, 48259180, 48415611, 49698844, 50045961, 50105250, 51050847, 57321254, 87218954, 90341370, 92308983, 92711322, 92729799, 103752630, 104300267, 116933600, 124749559, 124879445, 124879446, 125536869, 126630978
Target and Pathway
Target(s) Aromatic-L-amino-acid decarboxylase Target Info Inhibitor [535173]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Serotonin and melatonin biosynthesis
Catecholamine biosynthesis
KEGG Pathway Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine biosynthesis
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Catecholamine Biosynthesis
Tyrosine Metabolism
Tryptophan Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Tryptophan metabolism
Dopaminergic Neurogenesis
Metabolism of amino acids and derivatives
Dopamine metabolism
Parkinsons Disease Pathway
Nicotine Activity on Dopaminergic Neurons
References
Ref 468214(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5150).
Ref 521673ClinicalTrials.gov (NCT00144209) Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar DR) in Patients With Restless Legs Syndrome. U.S. National Institutes of Health.
Ref 535173Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22.

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