TTD | Drug: D0G5GV

Drug General Information
Drug ID	D0G5GV
Former ID	DIB018135
Drug Name	[123I]iodoproxyfan
Synonyms	[125I]-iodoproxyfan
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538779]
Structure		Download 2D MOL
Formula	C13H15IN2O
InChI	InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)/i14-4
InChIKey	DCQNAFOCXVCDLB-CKVWVWRJSA-N
PubChem Compound ID	449663
PubChem Substance ID	30, 36891171, 50537306, 104641267, 135651098
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Antagonist	[525918]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
Reactome	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538779	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1264).
Ref 525918	Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50.

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Drug Information