Drug Information

Drug General Information
Drug ID
D0I1TB
Former ID
DNC014351
Drug Name
5-(2-Methylquinolin-7-yl)-2-phenylnicotinonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530843]
Structure
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2D MOL

3D MOL
Formula
C22H15N3
Canonical SMILES
CC1=NC2=C(C=C1)C=CC(=C2)C3=CN=C(C(=C3)C#N)C4=CC=CC=C4
InChI
1S/C22H15N3/c1-15-7-8-16-9-10-18(12-21(16)25-15)20-11-19(13-23)22(24-14-20)17-5-3-2-4-6-17/h2-12,14H,1H3
InChIKey
NENPIXNGFVWRLL-UHFFFAOYSA-N
PubChem Compound ID
46888089
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530843]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530843Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
Ref 530843Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

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