Drug General Information
Drug ID	D0EK9T
Former ID	DNC010538
Drug Name	4-Phenyl-benzo[b]thiophene-2-carboxamidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530682]
Structure		Download 2D MOL 3D MOL
Formula	C15H12N2S
Canonical SMILES	C1=CC=C(C=C1)C2=C3C=C(SC3=CC=C2)C(=N)N
InChI	1S/C15H12N2S/c16-15(17)14-9-12-11(7-4-8-13(12)18-14)10-5-2-1-3-6-10/h1-9H,(H3,16,17)
InChIKey	HKXOXDHVUZHJFV-UHFFFAOYSA-N
PubChem Compound ID	15230353
Target and Pathway
Target(s)	Coagulation factor IX	Target Info	Inhibitor	[530682]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
Ref 530682	J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Ref 530682	J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.

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