Drug Information
Drug General Information | |||||
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Drug ID |
D0NE9T
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Former ID |
DAP000812
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Drug Name |
Fondaparinux sodium
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Synonyms |
Arixtra; Quixidar; Fondaparin sodium; Arixtra (TN); GSK-576428; SR-90107; SR-90107A; Fondaparinux sodium (JAN/USAN/INN)
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Drug Type |
Small molecular drug
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Indication | Venous thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Approved | [536361] | ||
Therapeutic Class |
Anticoagulants
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Company |
GSK
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Structure |
Download2D MOL |
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Formula |
C31H43N3Na10O49S8
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Canonical SMILES |
COC1C(C(C(C(O1)COS(=O)(=O)[O-])OC2C(C(C(C(O2)C(=O)[O-])<br />OC3C(C(C(C(O3)COS(=O)(=O)[O-])OC4C(C(C(C(O4)C(=O)[O-])O<br />C5C(C(C(C(O5)COS(=O)(=O)[O-])O)O)NS(=O)(=O)[O-])O)O)OS(<br />=O)(=O)[O-])NS(=O)(=O)[O-])O)OS(=O)(=O)[O-])O)NS(=O)(=O<br />)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[<br />Na+].[Na+]
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InChI |
1S/C31H53N3O49S8.10Na/c1-69-27-9(33-85(48,49)50)13(37)17(6(74-27)3-71-88(57,58)59)76-31-22(83-91(66,67)68)16(40)21(24(81-31)26(43)44)79-29-10(34-86(51,52)53)19(82-90(63,64)65)18(7(75-29)4-72-89(60,61)62)77-30-15(39)14(38)20(23(80-30)25(41)42)78-28-8(32-84(45,46)47)12(36)11(35)5(73-28)2-70-87(54,55)56;;;;;;;;;;/h5-24,27-40H,2-4H2,1H3,(H,41,42)(H,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68);;;;;;;;;;/q;10*+1/p-10/t5-,6-,7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-,19-,20+,21+,22-,23+,24-,27+,28-,29-,30-,31-;;;;;;;;;;/m1........../s1
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InChIKey |
XEKSTYNIJLDDAZ-JASSWCPGSA-D
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CAS Number |
CAS 114870-03-0
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
SuperDrug ATC ID |
B01AX05
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SuperDrug CAS ID |
cas=114870030
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Target and Pathway | |||||
Target(s) | Coagulation factor Xa | Target Info | Inhibitor | [535484], [535819] | |
KEGG Pathway | Complement and coagulation cascades | ||||
PANTHER Pathway | Blood coagulation | ||||
Pathway Interaction Database | Beta2 integrin cell surface interactions | ||||
PathWhiz Pathway | Coagulation | ||||
Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
Intrinsic Pathway of Fibrin Clot Formation | |||||
Common Pathway of Fibrin Clot Formation | |||||
Gamma-carboxylation of protein precursors | |||||
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
References | |||||
Ref 535484 | Fondaparinux, a synthetic pentasaccharide: the first in a new class of antithrombotic agents - the selective factor Xa inhibitors. Cardiovasc Drug Rev. 2002 Winter;20(1):37-52. | ||||
Ref 535819 | Biochemistry and clinical pharmacology of new anticoagulant agents. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):218-24. |
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