Drug Information

Drug General Information
Drug ID
D0C8UF
Former ID
DNC007964
Drug Name
Rac-2q
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528779]
Structure
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2D MOL

3D MOL
Formula
C20H18Cl2N2O7S
Canonical SMILES
C1C(C(=O)N(CC(=O)N1)S(=O)(=O)C2=CC=C(C=C2)Cl)CC3=C(C=CC<br />(=C3)Cl)OCC(=O)O
InChI
1S/C20H18Cl2N2O7S/c21-14-1-4-16(5-2-14)32(29,30)24-10-18(25)23-9-13(20(24)28)7-12-8-15(22)3-6-17(12)31-11-19(26)27/h1-6,8,13H,7,9-11H2,(H,23,25)(H,26,27)
InChIKey
MZKGVXPHEXNJSG-UHFFFAOYSA-N
PubChem Compound ID
44439966
Target and Pathway
Target(s) Chymase Target Info Inhibitor [528779]
KEGG Pathway Renin-angiotensin system
Reactome Activation of Matrix Metalloproteinases
Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 528779Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. Epub 2007 Mar 16.Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors.
Ref 528779Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. Epub 2007 Mar 16.Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors.

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