| Drug General Information |
| Drug ID |
D0G7NW
|
| Former ID |
DIB019672
|
| Drug Name |
cyamemazine
|
| Synonyms |
cyamepromazine; RP-7204
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H21N3S
|
| InChI |
InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
|
| InChIKey |
SLFGIOIONGJGRT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
8188334, 14826280, 43119930, 47285901, 47880135, 50006264, 51091644, 57314886, 75129996, 85209840, 96099841, 104326854, 125824719, 135019180, 135650143, 136158994, 136352157, 137006389, 142677092, 160676424, 162221098, 163133724, 164838618, 164838619, 172919690, 179225635, 184530546, 226509842, 249924678
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2A receptor |
Target Info |
Antagonist |
[2]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Antagonist |
[2]
|
| 5-hydroxytryptamine 7 receptor |
Target Info |
Antagonist |
[2]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
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Serotonergic synapsehsa04014:Ras signaling pathway
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Serotonergic synapsehsa04020:Calcium signaling pathway
|
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Inflammatory mediator regulation of TRP channels
|
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PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
|
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PathWhiz Pathway
|
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
|
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Reactome
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Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling events
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WikiPathways
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Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
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GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
|
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GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 84). |
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| REF 2 | Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40. |
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