Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0OB1J
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| Former ID |
DAP001262
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| Drug Name |
Diltiazem
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| Synonyms |
Acalix; Adizem; Aldizem; Anoheal; Cardil; Cardizem; Citizem; Dilacor; Dilcontin; Dilren; Diltia; Diltiazemum; Dilticard; Diltzac; Dilzen; Endrydil; Viazem; Cardizen LA; Incoril AP; Tiazac Tildiem; Tiazac XC; Adizem (TN); Altiazem (TN); Angiozem (TN); Angizem (TN); Angizem CD (TN); Apo-Diltiaz; Cardizem (Hydrochloride); Cardizem (TN); Cartia XT (TN); Dilacor-XR; Dilatam (TN); Dilatem (TN); Dilcardia (TN); Dilcontin SR (TN); Dilt-cd; Dilta-Hexal; Diltelan (TN); Diltiazem (INN); Diltiazem [INN:BAN]; Diltiazemum [INN-Latin]; Diltime (TN); Dilzem (TN); Dyalec (TN); Filazem (TN); Herben (TN); Nu-Diltiaz; Progor (TN); RG 83606 (Hydrochloride); Surazem (TN); Tiamate (TN); Tiazac (TN); Tiazac XC (TN); Tildiem (TN); Vasmulax (TN); Viazem (TN); Zandil (TN); Zemtrial (TN); D-cis-Diltiazem; MK-793 (Malate); [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate; Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester; (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Antihypertensive Agents
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| Company |
Valeant International Barbados Srl
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| Structure |
|
Download2D MOL |
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| Formula |
C22H26N2O4S
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| InChI |
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
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| InChIKey |
HSUGRBWQSSZJOP-RTWAWAEBSA-N
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| CAS Number |
CAS 42399-41-7
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9173, 596424, 3153198, 7979094, 8175919, 11113366, 11120251, 11120739, 11121227, 11466162, 11467282, 11485883, 14904463, 14929056, 25626811, 26751609, 26751610, 34705117, 46505667, 47364946, 47364947, 47959496, 48184777, 48258983, 48334236, 48415900, 49698365, 49890450, 50104266, 50104267, 50104268, 50104269, 50855582, 53788200, 57312277, 85306411, 85788735, 85788788, 89449648, 90341257, 92308825, 92309727, 92310310, 92711425, 93166706, 96024542, 99300641, 103164872, 103918269, 104331102
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| SuperDrug ATC ID |
C08DB01
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| SuperDrug CAS ID |
cas=042399417
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| Target and Pathway | |||||
| Target(s) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | Target Info | Blocker | [537595] | |
| PANTHER Pathway | Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| References | |||||
| Ref 536619 | Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol. 2008 Feb;6(2):e26. | ||||
| Ref 539449 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2298). | ||||
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