Drug Information

Drug General Information
Drug ID
D04PBD
Former ID
DIB020383
Drug Name
MLS1547
Synonyms
MLS000051547
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532749]
Structure
Download
2D MOL
Formula
C19H19ClN4O
InChI
InChI=1S/C19H19ClN4O/c20-16-12-14(19(25)18-15(16)4-3-7-22-18)13-23-8-10-24(11-9-23)17-5-1-2-6-21-17/h1-7,12,25H,8-11,13H2
InChIKey
OPEJNANYABTIGC-UHFFFAOYSA-N
PubChem Compound ID
1093278
PubChem Substance ID
3666529, 4110443, 4255655, 5124868, 8765477, 26632487, 26979540, 42137345, 47532652, 48128068, 53294329, 56381260, 87828176, 105262217, 110236273, 113635326, 121333729, 124818295, 130974503, 140708888, 144069819, 160671913, 164918354, 165230863, 167738012, 179413908, 238388307, 246464530, 252166581, 252450483, 252543692, 252617271
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [532749]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 532749Discovery and characterization of a G protein-biased agonist that inhibits beta-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014 Jul;86(1):96-105.
Ref 532749Discovery and characterization of a G protein-biased agonist that inhibits beta-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014 Jul;86(1):96-105.

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