Drug General Information
Drug ID	D0A8QA
Former ID	DNC014352
Drug Name	2-Chloro-5-(2-methylquinolin-7-yl)nicotinonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530843]
Structure		Download 2D MOL 3D MOL
Formula	C16H10ClN3
Canonical SMILES	CC1=NC2=C(C=C1)C=CC(=C2)C3=CN=C(C(=C3)C#N)Cl
InChI	1S/C16H10ClN3/c1-10-2-3-11-4-5-12(7-15(11)20-10)14-6-13(8-18)16(17)19-9-14/h2-7,9H,1H3
InChIKey	FCXAJLFDBPZDJD-UHFFFAOYSA-N
PubChem Compound ID	46888088
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[530843]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 530843	Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
Ref 530843	Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

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