Drug Information

Drug General Information
Drug ID
D00XVV
Former ID
DIB018131
Drug Name
[11C]WAY100635
Synonyms
[11C]WAY100635 (PET ligand); [11C]WAY-100635
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540225]
Structure
Download
2D MOL
Formula
C25H34N4O2
InChI
InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3/i25-1
InChIKey
SBPRIAGPYFYCRT-FNNGWQQSSA-N
PubChem Compound ID
449645
PubChem Substance ID
14, 1582, 10300373, 15827135, 22391573, 36891155, 77798687, 104641235, 178100297, 238394858
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [527424]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540225(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3252).
Ref 527424[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS. Brain. 2005 Apr;128(Pt 4):896-905. Epub 2005 Feb 2.

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