Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06KBO
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| Former ID |
DIB020692
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| Drug Name |
PGD2
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| Synonyms |
11-dehydroprostaglandin F2-alpha; BRN 2170623; prostaglandin D2
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539182] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H32O5
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| InChI |
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
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| InChIKey |
BHMBVRSPMRCCGG-OUTUXVNYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3964, 583767, 4265955, 7889816, 7980420, 8143213, 10300216, 12012669, 15496745, 24898605, 26754808, 26754809, 36890302, 46504574, 47515086, 48258962, 49700655, 50026788, 50110785, 53788536, 57404870, 77723738, 92297650, 92309902, 99300816, 99302334, 104046434, 104639469, 123099371, 126524027, 127277724, 127277725, 127277726, 127277727, 127277728, 127277729, 127277730, 127277731, 127277732, 127277733, 127346781, 127346782, 127346783, 135001740, 135651538, 135651568, 137005673, 142697392, 143486570, 160965276
|
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| Target and Pathway | |||||
| Target(s) | Prostaglandin D2 receptor | Target Info | Agonist | [525559] | |
| Prostaglandin E2 receptor, EP4 subtype | Target Info | Agonist | [534595] | ||
| Putative G-protein coupled receptor 44 | Target Info | Agonist | [527831] | ||
| Prostaglandin F2-alpha receptor | Target Info | Agonist | [534478] | ||
| Prostaglandin E2 receptor, EP1 subtype | Target Info | Agonist | [526324] | ||
| Prostaglandin E2 receptor EP3 subtype | Target Info | Agonist | [534595] | ||
| Prostaglandin E2receptor, EP2 subtype | Target Info | Agonist | [525571] | ||
| KEGG Pathway | Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| Renin secretion | |||||
| Pathways in cancerhsa04020:Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| cAMP signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Pathways in cancerhsa04024:cAMP signaling pathway | |||||
| Pathways in cancer | |||||
| PANTHER Pathway | PI3 kinase pathway | ||||
| Pathway Interaction Database | Thromboxane A2 receptor signaling | ||||
| PathWhiz Pathway | Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation | |||||
| Vitamin D Receptor Pathway | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation | |||||
| Ovarian Infertility Genes | |||||
| References | |||||
| Ref 525559 | A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. Eur J Pharmacol. 1999 Jul 14;377(1):101-15. | ||||
| Ref 525571 | Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51. | ||||
| Ref 526324 | Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. J Pharm Pharmacol. 2002 Apr;54(4):539-47. | ||||
| Ref 527831 | CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. Epub 2005 Oct 27. | ||||
| Ref 534478 | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. | ||||
| Ref 534595 | Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. | ||||
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