Drug Information

Drug General Information
Drug ID
D0H4TP
Former ID
DNC002343
Drug Name
GSK189254A
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Investigative [536039]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C21H25N3O2
Canonical SMILES
CNC(=O)C1=CN=C(C=C1)OC2=CC3=C(CCN(CC3)C4CCC4)C=C2
InChI
1S/C21H25N3O2/c1-22-21(25)17-6-8-20(23-14-17)26-19-7-5-15-9-11-24(18-3-2-4-18)12-10-16(15)13-19/h5-8,13-14,18H,2-4,9-12H2,1H3,(H,22,25)
InChIKey
WROHEWWOCPRMIA-UHFFFAOYSA-N
PubChem Compound ID
9798547
PubChem Substance ID
14754269, 24107979, 44834554, 77930281, 103590505, 104102227, 134223854, 134346504, 135263917, 137008771, 140656125, 144116028, 162221937, 163642557, 198968915, 223999219, 226531257, 247076616, 251963076, 252110127, 252451758
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [536039]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.

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