Drug Information

Drug General Information
Drug ID
D01AMV
Former ID
DNC014274
Drug Name
3-(6-fluoroquinazolin-4-ylamino)benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530473]
Structure
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2D MOL

3D MOL
Formula
C15H9FN4
Canonical SMILES
C1=CC(=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)F)C#N
InChI
1S/C15H9FN4/c16-11-4-5-14-13(7-11)15(19-9-18-14)20-12-3-1-2-10(6-12)8-17/h1-7,9H,(H,18,19,20)
InChIKey
NWRSWZMZACUZPY-UHFFFAOYSA-N
PubChem Compound ID
46879811
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530473]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

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