Drug Information

Drug General Information
Drug ID
D07XUM
Former ID
DIB019854
Drug Name
FG-5893
Synonyms
FG5893; FG 5893
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538797]
Structure
Download
2D MOL
Formula
C27H29F2N3O2
InChI
InChI=1S/C27H29F2N3O2/c1-34-27(33)25-4-2-14-30-26(25)32-18-16-31(17-19-32)15-3-5-24(20-6-10-22(28)11-7-20)21-8-12-23(29)13-9-21/h2,4,6-14,24H,3,5,15-19H2,1H3
InChIKey
NDCPNKXUTJGQQC-UHFFFAOYSA-N
PubChem Compound ID
127728
PubChem Substance ID
10241842, 14907260, 29306944, 57342296, 79334939, 85209580, 104366494, 128685013, 135082440, 135650260, 198980428, 233344250
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534714]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538797(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 13).
Ref 534714Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56.

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