TTD | Drug: D05OBK

Drug General Information
Drug ID	D05OBK
Former ID	DCL000520
Drug Name	DwLIP-GCGRrx
Drug Type	Small molecular drug
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Investigative	[551054]
Company	ISIS
Structure		Download 2D MOL 3D MOL
Formula	C18H22Cl2N4O2
Canonical SMILES	C[NH+](C)CCC[NH2+]C1=C2C(=NC3=CC=CC=C31)C=CC=C2[N+](=O)<br />[O-].[Cl-].[Cl-]
InChI	1S/C18H20N4O2.2ClH/c1-21(2)12-6-11-19-18-13-7-3-4-8-14(13)20-15-9-5-10-16(17(15)18)22(23)24;;/h3-5,7-10H,6,11-12H2,1-2H3,(H,19,20);2*1H
InChIKey	XBHIADYHFGJGSK-UHFFFAOYSA-N
PubChem Compound ID	23015
PubChem Substance ID	8166838, 29290208, 49864326, 50649306, 57331286, 104357360, 134339103, 134986773, 137267773, 227840977
Target and Pathway
Target(s)	Glucagon receptor	Target Info	Binder	[551054]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Glucagon signaling pathway
Reactome	Glucagon signaling in metabolic regulation
	G alpha (q) signalling events
	G alpha (s) signalling events
	Glucagon-type ligand receptors
WikiPathways	GPCRs, Class B Secretin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551054	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
Ref 551054	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).

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Drug Information