| Drug General Information |
| Drug ID |
D0FY0R
|
| Former ID |
DNC001478
|
| Drug Name |
Tyrphostin AG490
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H14N2O3
|
| Canonical SMILES |
C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
|
| InChI |
1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
|
| InChIKey |
TUCIOBMMDDOEMM-RIYZIHGNSA-N
|
| CAS Number |
CAS 133550-30-8
|
| PubChem Compound ID |
|
| PubChem Substance ID |
629517, 8033990, 11061045, 11111876, 11113487, 14849288, 17405722, 24278732, 26751707, 26751708, 26759681, 39301404, 47290860, 47588720, 47810470, 47810471, 47885126, 48110172, 50104393, 50104394, 50104395, 53778272, 53789794, 56314167, 56463448, 57361285, 71751762, 78726229, 80953720, 85231253, 85787739, 88804259, 90341519, 92303385, 92309812, 99300726, 99302244, 99302805, 99436917, 103244043, 104051609, 113910669, 118311117, 124658725, 124757030, 124799933, 124881621, 124881622, 124881623, 124881624
|
| Target and Pathway |
| Target(s) |
Tyrosine-protein kinase JAK2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Cholinergic synapse
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Leishmaniasis
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Toxoplasmosis
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Tuberculosis
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Measles
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Influenza A
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Herpes simplex infection
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Interferon-gamma signaling pathway
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JAK/STAT signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Endothelins
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ErbB4 signaling events
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GMCSF-mediated signaling events
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IL4-mediated signaling events
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IL27-mediated signaling events
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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S1P3 pathway
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SHP2 signaling
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Notch-mediated HES/HEY network
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Reactome
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Interleukin-6 signaling
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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GPVI-mediated activation cascade
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Prolactin receptor signaling
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RMTs methylate histone arginines
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G beta:gamma signalling through PI3Kgamma
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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RAF/MAP kinase cascade
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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Serotonin Receptor 2 and STAT3 Signaling
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Type II interferon signaling (IFNG)
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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IL-4 Signaling Pathway
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IL-6 signaling pathway
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Kit receptor signaling pathway
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IL-3 Signaling Pathway
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Mesodermal Commitment Pathway
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Interleukin-2 signaling
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Signaling by SCF-KIT
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Prolactin receptor signaling
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Growth hormone receptor signaling
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JAK/STAT
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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TSLP Signaling Pathway
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IL17 signaling pathway
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Leptin signaling pathway
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TSH signaling pathway
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Interleukin-3, 5 and GM-CSF signaling
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Interferon gamma signaling
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Factors involved in megakaryocyte development and platelet production
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IL-5 Signaling Pathway
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| References |
| REF 1 | The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia. 2001 Nov;15(11):1758-68. |
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