Drug Information

Drug General Information
Drug ID
D05TZN
Former ID
DNC005172
Drug Name
Des-Arg10-Kallidin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541580]
Structure
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2D MOL

3D MOL
Formula
C50H73N13O11
InChI
InChI=1S/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
InChIKey
AILVBOHFGXNHCC-TZPCGENMSA-N
PubChem Compound ID
122227
PubChem Substance ID
7979355, 7979675, 15040396, 29302653, 50112557, 57340028, 80710943, 85083106, 103454291, 103827582, 104043581, 104415336, 134342377, 135076605, 135652109, 144225993, 162227420, 241130779, 241376323, 249617790, 252157107
Target and Pathway
Target(s) B1 bradykinin receptor Target Info Inhibitor [527294]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways Complement and Coagulation Cascades
ACE Inhibitor Pathway
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541580(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 644).
Ref 527294Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8.Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.

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