| Drug General Information |
| Drug ID |
D00WEQ
|
| Former ID |
DNC011760
|
| Drug Name |
Brolamfetamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H16BrNO2
|
| InChI |
InChI=1S/C11H16BrNO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
|
| InChIKey |
FXMWUTGUCAKGQL-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
3249526, 7516923, 8187862, 10518483, 10531667, 15071198, 43119241, 46507989, 47359939, 47805577, 50064682, 50113080, 50566377, 57314585, 85208881, 103164704, 103918766, 104324859, 117388967, 124893454, 127913862, 134223389, 134348965, 135028812, 135057191, 135650198, 135651149, 137005383, 160964741, 164840081, 179293614, 227004198, 241061107, 249912203, 252330132
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1D receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[3]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathway
|
|
Reactome
|
Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
|
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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SIDS Susceptibility Pathways
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Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 163). |
|---|
| REF 2 | J Med Chem. 1986 Feb;29(2):194-9.5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. |
|---|
| REF 3 | Bioorg Med Chem. 2008 Jun 1;16(11):6242-51. Epub 2008 May 6.'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines. |
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