Drug Information

Drug General Information
Drug ID
D0P3XL
Former ID
DNC000097
Drug Name
6-bromoindirubin-3'-oxime (BIO)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537261]
Structure
Download
2D MOL

3D MOL
Formula
C16H10BrN3O2
Canonical SMILES
C1=CC2=C(C(=C3C4=C(C=C(C=C4)Br)NC3=O)N=C2C=C1)NO
InChI
1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)/b15-13-
InChIKey
WNWSUJQVZJJGLF-SQFISAMPSA-N
PubChem Compound ID
5287844
PubChem Substance ID
833555, 7886348, 14747233, 15002478, 24724412, 26753605, 26753606, 26758803, 26758805, 29215160, 39320384, 46393346, 46507596, 48244433, 48431446, 56339573, 57359194, 57550078, 76874466, 85752750, 85756489, 90341740, 91148008, 99302717, 103029097, 103566428, 104074524, 104092357, 113870608, 121361652, 121560411, 123103467, 123220362, 124659179, 134344759, 135698600, 141713899, 141713900, 141713902, 141713903, 141713904, 160966566, 163338681, 163564727, 163688038, 163688040, 172089031, 172916913, 174520444, 175607663
Target and Pathway
Target(s) Glycogen synthase kinase-3 Target Info Inhibitor [537261]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
References
Ref 537261Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor. Genesis. 2009 Jun;47(6):414-22.
Ref 537261Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor. Genesis. 2009 Jun;47(6):414-22.

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