Drug Information

Drug General Information
Drug ID
D02KMG
Former ID
DCL000563
Drug Name
Milveterol
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease; Asthma [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Discontinued in Phase 2 [537130]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C25H29N3O4
Canonical SMILES
C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=<br />O)O)O
InChI
1S/C25H29N3O4/c29-17-28-22-14-20(8-11-23(22)30)24(31)15-26-13-12-18-6-9-21(10-7-18)27-16-25(32)19-4-2-1-3-5-19/h1-11,14,17,24-27,30-32H,12-13,15-16H2,(H,28,29)/t24-,25-/m0/s1
InChIKey
BMKINZUHKYLSKI-DQEYMECFSA-N
PubChem Compound ID
9892481
PubChem Substance ID
16714686, 24177713, 45639416, 77039674, 134339125, 135299619, 136936002, 137001885, 141756409, 163368676, 198962950, 223912945, 226613349, 246236383
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [550963]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 537130Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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