Drug Information

Drug General Information
Drug ID
D01OIK
Former ID
DIB021227
Drug Name
xamoterol
Synonyms
ICI-118587
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540793]
Structure
Download
2D MOL
Formula
C16H25N3O5
InChI
InChI=1S/C16H25N3O5/c20-13-1-3-15(4-2-13)24-12-14(21)11-17-5-6-18-16(22)19-7-9-23-10-8-19/h1-4,14,17,20-21H,5-12H2,(H,18,22)
InChIKey
DXPOSRCHIDYWHW-UHFFFAOYSA-N
PubChem Compound ID
155774
PubChem Substance ID
13939, 5764875, 7978511, 10252742, 11466951, 11468071, 11486741, 14827117, 26751988, 46231703, 47207985, 47573382, 47646564, 47646565, 47720617, 48393937, 49699400, 50065257, 50104665, 50602287, 81065487, 85209357, 92308849, 103277522, 104171266, 104442200, 124750362, 124881833, 124881834, 125754602, 127801713, 135014177, 135651330, 137240023, 142970903, 144203855, 162168886, 163176430, 176484564, 179151043, 184547508, 203083278, 223441156, 224877570, 226445716
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [525620]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 538).
Ref 525620Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists. Mol Pharmacol. 1999 Nov;56(5):875-85.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.