| Drug General Information |
| Drug ID |
D0Q5DI
|
| Former ID |
DIB020523
|
| Drug Name |
nexturastat A
|
| Synonyms |
S7473
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H23N3O3
|
| InChI |
InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
|
| InChIKey |
JZWXMCPARMXZQV-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
163338793, 163347740, 163501714, 177218166, 184024322, 184024343, 184525742, 184525763, 184525784, 187051806, 210275560, 210281208, 223366959, 226088094, 240242956, 251962694, 252160951, 252448869, 252451435, 252472671
|
| Target and Pathway |
| Target(s) |
Histone deacetylase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Histone deacetylase 6 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Cell cycle
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Notch signaling pathway
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Thyroid hormone signaling pathway
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Huntington's disease
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Amphetamine addiction
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Alcoholism
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Epstein-Barr virus infection
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Pathways in cancer
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Transcriptional misregulation in cancer
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Viral carcinogenesis
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MicroRNAs in cancer
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Chronic myeloid leukemiahsa05034:Alcoholism
|
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Wnt signaling pathway
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p53 pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Notch signaling pathway
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E2F transcription factor network
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Presenilin action in Notch and Wnt signaling
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Signaling events mediated by HDAC Class I
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Sumoylation by RanBP2 regulates transcriptional repression
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Regulation of Androgen receptor activity
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IL3-mediated signaling events
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Validated nuclear estrogen receptor alpha network
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Retinoic acid receptors-mediated signaling
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Hedgehog signaling events mediated by Gli proteins
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Regulation of nuclear beta catenin signaling and target gene transcription
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Validated targets of C-MYC transcriptional repression
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Regulation of retinoblastoma protein
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Notch-mediated HES/HEY networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
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Reactome
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G0 and Early G1
|
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p75NTR negatively regulates cell cycle via SC1
|
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Formation of the beta-catenin:TCF transactivating complex
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NOTCH1 Intracellular Domain Regulates Transcription
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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HDACs deacetylate histones
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Deactivation of the beta-catenin transactivating complex
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NoRC negatively regulates rRNA expression
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RNA Polymerase I Transcription Initiation
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Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
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Assembly of the primary cilium
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WikiPathways
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SIDS Susceptibility Pathways
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Notch Signaling Pathway
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TGF beta Signaling Pathway
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IL-6 signaling pathway
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Apoptosis-related network due to altered Notch3 in ovarian cancer
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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Notch Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Neural Crest Differentiation
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TWEAK Signaling Pathway
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Integrated Breast Cancer Pathway
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Signalling by NGF
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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Mitotic G1-G1/S phases
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Factors involved in megakaryocyte development and platelet production
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Cell Cycle
|
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Androgen receptor signaling pathwayWP2858:Ectoderm Differentiation
|
| References |
| REF 1 | Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. |
|---|
