Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06JMV
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| Former ID |
DNC012882
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| Drug Name |
PB-27
|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C26H25N7O2S
|
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| Canonical SMILES |
CN1C=NC=C1CN2CC(CC3=C2C=CC(=C3)C#N)N(CC4=CC=CC=N4)S(=O)<br />(=O)C5=CC=CC=N5
|
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| InChI |
1S/C26H25N7O2S/c1-31-19-28-15-24(31)18-32-17-23(13-21-12-20(14-27)8-9-25(21)32)33(16-22-6-2-4-10-29-22)36(34,35)26-7-3-5-11-30-26/h2-12,15,19,23H,13,16-18H2,1H3
|
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| InChIKey |
GQLZRVHYGCXHSR-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Farnesyltransferase | Target Info | Inhibitor | [1] | |
| Protein farnesyltransferase beta subunit | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Terpenoid backbone biosynthesis | ||||
| Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis | |||||
| Biosynthesis of antibiotics | |||||
| NetPath Pathway | TSH Signaling Pathway | ||||
| Reactome | Apoptotic cleavage of cellular proteins | ||||
| Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade | |||||
| WikiPathways | Visual phototransduction | ||||
| Apoptotic execution phaseWP2776:Visual phototransduction | |||||
| References | |||||
| REF 1 | J Med Chem. 2005 Jun 2;48(11):3704-13.Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. | ||||
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