Drug General Information |
Drug ID |
D0HM8Y
|
Former ID |
DNC006328
|
Drug Name |
3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C14H10O4
|
Canonical SMILES |
CC1=C(C=CC2=C1C(=O)OC3=C2C=CC(=C3)O)O
|
InChI |
1S/C14H10O4/c1-7-11(16)5-4-10-9-3-2-8(15)6-12(9)18-14(17)13(7)10/h2-6,15-16H,1H3
|
InChIKey |
UQGMRVBIHYSKJN-UHFFFAOYSA-N
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
Estrogen receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Estrogen signaling pathway
|
Prolactin signaling pathwayhsa04915:Estrogen signaling pathway
|
Prolactin signaling pathway
|
Thyroid hormone signaling pathway
|
Endocrine and other factor-regulated calcium reabsorption
|
Proteoglycans in cancer
|
NetPath Pathway
|
FSH Signaling Pathway
|
EGFR1 Signaling Pathway
|
RANKL Signaling Pathway
|
Pathway Interaction Database
|
Plasma membrane estrogen receptor signaling
|
Validated nuclear estrogen receptor beta network
|
Validated nuclear estrogen receptor alpha networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
Signaling events mediated by HDAC Class II
|
LKB1 signaling events
|
Regulation of Telomerase
|
ATF-2 transcription factor network
|
AP-1 transcription factor network
|
FOXM1 transcription factor network
|
Validated nuclear estrogen receptor alpha network
|
Signaling mediated by p38-alpha and p38-beta
|
FOXA1 transcription factor network
|
Reactome
|
Nuclear Receptor transcription pathwayR-HSA-1251985:Nuclear signaling by ERBB4
|
Nuclear Receptor transcription pathway
|
WikiPathways
|
SIDS Susceptibility Pathways
|
Ovarian Infertility Genes
|
Integrated Pancreatic Cancer Pathway
|
Nuclear ReceptorsWP712:Estrogen signaling pathway
|
Nuclear Receptors Meta-Pathway
|
Estrogen Receptor Pathway
|
Signaling by ERBB4
|
JAK/STAT
|
Leptin signaling pathway
|
miR-targeted genes in muscle cell - TarBase
|
Integrated Breast Cancer Pathway
|
Nuclear Receptors
|
References |
REF 1 | Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. |