Drug Information

Drug General Information
Drug ID
D0A7FQ
Former ID
DNC009913
Drug Name
CGP-57380
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541275]
Structure
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2D MOL

3D MOL
Formula
C11H9FN6
InChI
InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
InChIKey
UQPMANVRZYYQMD-UHFFFAOYSA-N
PubChem Compound ID
11644425
PubChem Substance ID
16747733, 24724432, 26755726, 26759139, 50111280, 53800676, 56459389, 57376956, 80182634, 85787679, 90340880, 91146247, 93580909, 98577757, 99302780, 104139754, 121361998, 121502913, 123088148, 123105546, 125333931, 126700079, 135293020, 135698461, 138753860, 141444807, 162023548, 162248028, 163565210, 163687710, 172659616, 175607498, 178102632, 179694529, 180387049, 182111932, 184525797, 184525815, 184525833, 184525852, 208264893, 223398381, 227243988, 241376098, 244223337, 247192106, 252156746, 252160297, 252457400, 252471053
Target and Pathway
Target(s) mRNA of Aurora B Target Info Inhibitor [529039]
Serine/threonine-protein kinase Sgk1 Target Info Inhibitor [529039]
Lck tyrosine kinase Target Info Inhibitor [529039]
KEGG Pathway FoxO signaling pathway
PI3K-Akt signaling pathway
Aldosterone-regulated sodium reabsorptionhsa04064:NF-kappa B signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
HTLV-I infection
Primary immunodeficiency
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Parkinson disease
T cell activation
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Aurora C signaling
FOXM1 transcription factor network
Aurora A signalinginsulin_pathway:Insulin Pathway
Glucocorticoid receptor regulatory network
mTOR signaling pathway
FoxO family signaling
Class I PI3K signaling eventsnfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
SHP2 signaling
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic PrometaphaseR-HSA-2672351:Stimuli-sensing channelsR-HSA-114604:GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signaling
WikiPathways Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteinsWP481:Insulin Signaling
Iron uptake and transport
FSH signaling pathwayWP61:Notch Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TCR signaling
Costimulation by the CD28 family
References
Ref 541275(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6010).
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.

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