Drug Information

Drug General Information
Drug ID
D0Q6VH
Former ID
DNC013058
Drug Name
SIB-1893
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538910]
Structure
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2D MOL

3D MOL
Formula
C14H13N
InChI
InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
InChIKey
SISOFUCTXZKSOQ-ZHACJKMWSA-N
PubChem Compound ID
5311432
PubChem Substance ID
93264, 7980596, 11056503, 14748605, 17405727, 24278718, 26752109, 39341108, 47944897, 48020080, 48244486, 50104764, 50104765, 53778277, 53790542, 57359481, 78678348, 85209303, 85788643, 90341151, 91722414, 92303402, 99355658, 103120636, 103296741, 103983725, 114156082, 117520149, 121361987, 124750290, 124886985, 132562594, 134350263, 135314104, 135651042, 135698407, 136352764, 137131725, 137132953, 138302982, 162249251, 163565125, 164848759, 172881068, 172914475, 179294106, 184595717, 241182237, 249581820
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528186]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538910(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1432).
Ref 528186Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. Epub 2006 May 5.Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

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