Drug General Information
Drug ID	D0X9UJ
Former ID	DNC009692
Drug Name	PD-068235
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529363]
Structure		Download 2D MOL 3D MOL
Formula	C11H15N3O3S
Canonical SMILES	CC(C)(C)C(=O)N=C1N(C=C(S1)[N+](=O)[O-])CC=C
InChI	1S/C11H15N3O3S/c1-5-6-13-7-8(14(16)17)18-10(13)12-9(15)11(2,3)4/h5,7H,1,6H2,2-4H3
InChIKey	SPVZIILAYYBEDM-UHFFFAOYSA-N
PubChem Compound ID	44581800
Target and Pathway
Target(s)	mRNA of PPAR-gamma	Target Info	Inhibitor	[529363]
KEGG Pathway	PPAR signaling pathway
	AMPK signaling pathway
	Osteoclast differentiation
	Huntington's disease
	Pathways in cancer
	Transcriptional misregulation in cancer
	Thyroid cancer
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	CCKR signaling map ST
Pathway Interaction Database	Noncanonical Wnt signaling pathway
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Signaling events mediated by HDAC Class I
	RXR and RAR heterodimerization with other nuclear receptor
	Regulation of retinoblastoma protein
Reactome	PPARA activates gene expression
	Transcriptional regulation of white adipocyte differentiation
	Nuclear Receptor transcription pathway
WikiPathways	Wnt Signaling Pathway Netpath
	Nuclear Receptors in Lipid Metabolism and Toxicity
	Differentiation of white and brown adipocyte
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Transcriptional Regulation of White Adipocyte Differentiation
	Adipogenesis
	SREBP signalling
	Nuclear Receptors
References
Ref 529363	Eur J Med Chem. 2008 Dec;43(12):2699-716. Epub 2008 Feb 3.Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.
Ref 529363	Eur J Med Chem. 2008 Dec;43(12):2699-716. Epub 2008 Feb 3.Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling.

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