Drug Information
Drug General Information | |||||
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Drug ID |
D03HJW
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Former ID |
DIB019941
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Drug Name |
GSK1016790A
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [467539] | ||
Structure |
Download2D MOL |
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Formula |
C28H32Cl2N4O6S2
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InChI |
InChI=1S/C28H32Cl2N4O6S2/c1-17(2)13-21(31-26(36)24-14-18-5-3-4-6-23(18)41-24)27(37)33-9-11-34(12-10-33)28(38)22(16-35)32-42(39,40)25-8-7-19(29)15-20(25)30/h3-8,14-15,17,21-22,32,35H,9-13,16H2,1-2H3,(H,31,36)/t21-,22-/m0/s1
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InChIKey |
IVYQPSHHYIAUFO-VXKWHMMOSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Transient receptor potential cation channel subfamily V member 4 | Target Info | Activator | [529487] | |
KEGG Pathway | Inflammatory mediator regulation of TRP channels | ||||
Reactome | TRP channels | ||||
References | |||||
Ref 529487 | N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42. |
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