Drug Information

Drug General Information
Drug ID
D02YIW
Former ID
DIB018634
Drug Name
5-(N,N-hexamethylene)-amiloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538703]
Structure
Download
2D MOL
Formula
C12H18ClN7O
InChI
InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
InChIKey
RQQJJXVETXFINY-UHFFFAOYSA-N
PubChem Compound ID
1794
PubChem Substance ID
3721421, 5244802, 8151288, 11110798, 11342050, 11362233, 11364490, 11367052, 11369614, 11372762, 11374345, 11377776, 11485593, 11487635, 11489485, 11491477, 11492438, 11495410, 14776630, 17404667, 24278246, 26612673, 26680153, 26749339, 29220993, 47291316, 47500609, 47736700, 48110661, 48334713, 50064415, 50105831, 50105832, 50107574, 53777210, 56463449, 57321027, 71822511, 79418853, 85086636, 85230925, 85788510, 90340799, 92303675, 93166515, 103128691, 103615298, 104298740, 117465724, 121360894
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Modulator (allosteric modulator) [529377]
Alpha-2C adrenergic receptor Target Info Modulator (allosteric modulator) [534623]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathwayhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
References
Ref 538703(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1192).
Ref 529377Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol. 2008 Jun;73(6):1808-15.
Ref 534623Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor. Mol Pharmacol. 1998 May;53(5):916-25.

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