Drug General Information |
Drug ID |
D0T6ZX
|
Former ID |
DNC005052
|
Drug Name |
HYDROSULFIDE
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
HS-
|
Canonical SMILES |
[SH-]
|
InChI |
1S/H2S/h1H2/p-1
|
InChIKey |
RWSOTUBLDIXVET-UHFFFAOYSA-M
|
PubChem Compound ID |
|
Target and Pathway |
Target(s) |
Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
Carbonic anhydrase I |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Nitrogen metabolismhsa00910:Nitrogen metabolism
|
Proximal tubule bicarbonate reclamation
|
Collecting duct acid secretion
|
Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa00910:Nitrogen metabolism
|
NetPath Pathway
|
IL4 Signaling Pathway
|
EGFR1 Signaling Pathway
|
Pathway Interaction Database
|
HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
|
PathWhiz Pathway
|
Gastric Acid Production
|
Reactome
|
Regulation of gene expression by Hypoxia-inducible Factor
|
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
Erythrocytes take up oxygen and release carbon dioxide
|
Reversible hydration of carbon dioxide
|
WikiPathways
|
Vitamin D Receptor Pathway
|
Reversible Hydration of Carbon Dioxide
|
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
|
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
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Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
References |
REF 1 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73.Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. |
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REF 2 | Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. |