Drug Information

Drug General Information
Drug ID
D0U2OO
Former ID
DAP000031
Drug Name
Buspirone
Synonyms
Ansial; Ansiced; Anxiron; Axoren; Bespar; Buspirona; Buspironum; Buspisal; Ansial (TN); Ansiced (TN); Anxiron (TN); Axoren (TN); Bespar (TN); BuSpar (TN); Buspimen (TN); Buspinol (TN); Buspiron (TN); Buspirona [INN-Spanish]; Buspirone (INN); Buspirone [INN:BAN]; Buspirone-MDTS; Buspironum [INN-Latin]; Buspisal (TN); Gen-Buspirone; Narol (TN); Sorbon (TN); Spamilan (TN); Spitomin (TN); Gen-Buspirone (TN); MJ-9022-1; N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide; 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione; 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione; 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione; 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Approved [536505], [540478]
Therapeutic Class
Antianxiety Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C21H31N5O2
InChI
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
InChIKey
QWCRAEMEVRGPNT-UHFFFAOYSA-N
CAS Number
CAS 36505-84-7
PubChem Compound ID
2477
PubChem Substance ID
9079, 4652644, 7978828, 8151653, 10589701, 11110857, 11112732, 11113821, 11336096, 11361335, 11364650, 11367212, 11369774, 11377936, 11462307, 11466397, 11467517, 11486154, 11495570, 11533496, 14902734, 24714738, 25671043, 26751994, 29221641, 46508113, 47365265, 47365266, 47440338, 47589062, 47662354, 48259310, 48259311, 48259312, 48415667, 49698848, 49872682, 50104669, 51066541, 51091905, 53790629, 57321342, 85209802, 85787807, 85788842, 90340780, 92309215, 93166677, 103166970, 103916226
ChEBI ID
ChEBI:3223
SuperDrug ATC ID
N05BE01
SuperDrug CAS ID
cas=036505847
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [536213]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536505Glutamate and anxiety disorders. Curr Psychiatry Rep. 2007 Aug;9(4):278-83.
Ref 540478(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 36).
Ref 536213Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204.

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