Drug Information

Drug General Information
Drug ID
D08XLL
Former ID
DIB020006
Drug Name
hGCGR antagonist
Synonyms
acylated aminothiophene nitrile; hGCGR antagonist; glucagon receptor antagonist I
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538682]
Structure
Download
2D MOL
Formula
C20H30N2OS
InChI
InChI=1S/C20H30N2OS/c1-6-13(7-2)18(23)22-19-16(12-21)15-10-9-14(11-17(15)24-19)20(4,5)8-3/h13-14H,6-11H2,1-5H3,(H,22,23)
InChIKey
SWIBDWBSJSJQHL-UHFFFAOYSA-N
PubChem Compound ID
619101
PubChem Substance ID
6133570, 8699848, 16476344, 26758781, 43449883, 48227344, 57953349, 80455923, 88381724, 103443594, 104047799, 107845280, 109840323, 118639420, 125504010, 135650674, 163122420, 163688062, 169981634, 184621871, 204371715, 212342276, 228738412, 246725891, 250099803
Target and Pathway
Target(s) Glucagon receptor Target Info Antagonist [527303]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 538682(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1148).
Ref 527303A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73.

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