Drug Information

Drug General Information
Drug ID
D08ADI
Former ID
DNC006423
Drug Name
3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527989]
Structure
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2D MOL

3D MOL
Formula
C19H16ClNO
Canonical SMILES
CC1=CC(=CC(=C1)C2=CN=CC=C2)OCC3=CC(=CC=C3)Cl
InChI
1S/C19H16ClNO/c1-14-8-17(16-5-3-7-21-12-16)11-19(9-14)22-13-15-4-2-6-18(20)10-15/h2-12H,13H2,1H3
InChIKey
XCVOOHGTUQHYAX-UHFFFAOYSA-N
PubChem Compound ID
44409820
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [527989]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527989Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
Ref 527989Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. Epub 2006 Jan 24.Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

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