Drug General Information
Drug ID
D0Y4CC
Former ID
DNC013344
Drug Name
N-[4-(1H-benzoimidazol-2-yl)-benzoyl]-guanidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528720]
Structure
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2D MOL

3D MOL

Formula
C15H13N5O
Canonical SMILES
C1=CC=C2C(=C1)NC(=N2)C3=CC=C(C=C3)C(=O)N=C(N)N
InChI
1S/C15H13N5O/c16-15(17)20-14(21)10-7-5-9(6-8-10)13-18-11-3-1-2-4-12(11)19-13/h1-8H,(H,18,19)(H4,16,17,20,21)
InChIKey
RAYGWMJYTDFZDD-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Sodium/hydrogen exchanger 1 Target Info Inhibitor [528720]
KEGG Pathway cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Proteoglycans in cancer
Pathway Interaction Database Endothelins
RhoA signaling pathway
ErbB1 downstream signaling
Signaling mediated by p38-alpha and p38-beta
Reactome Hyaluronan uptake and degradation
WikiPathways Regulation of Actin Cytoskeleton
G Protein Signaling Pathways
Glycosaminoglycan metabolism
Osteoclast Signaling
References
Ref 528720Bioorg Med Chem Lett. 2007 May 1;17(9):2430-3. Epub 2007 Feb 17.Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.
Ref 528720Bioorg Med Chem Lett. 2007 May 1;17(9):2430-3. Epub 2007 Feb 17.Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.

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