Drug General Information
Drug ID	D03MCV
Former ID	DCL000212
Drug Name	RB-006
Indication	Thrombosis; Coronary artery disease; Vascular diseases [ICD9: 325, 410-414, 429.2, 430-459, 437.6, 453, 671.5, 671.9; ICD10:G45-G46, I20-I25, I60-I95, I80-I82]		Discontinued in Phase 3	[547853]
Company	Regado Biosci
Structure		Download 2D MOL
Target and Pathway
Target(s)	Coagulation factor IX	Target Info	Inhibitor	[537273]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
Ref 547853	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019932)
Ref 537273	In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. Thromb Haemost. 2009 May;101(5):827-33.

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