Drug Information

Drug General Information
Drug ID
D0P0SZ
Former ID
DAP001504
Drug Name
Piperaquine
Synonyms
Piperaquinoline; Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-); Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-(9CI); 1,3-bis(1-(7-chloro-4'-quinolyl)-4'-piperazinyl)propane; 1,3-bis(4-(7'-chloro-4'-quinoline)-1-piperazine); 4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline); 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Approved [536602]
Structure
Download
2D MOL

3D MOL
Formula
C29H32Cl2N6
Canonical SMILES
C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC<br />(=CC6=NC=C5)Cl
InChI
1S/C29H32Cl2N6/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29/h2-9,20-21H,1,10-19H2
InChIKey
UCRHFBCYFMIWHC-UHFFFAOYSA-N
CAS Number
CAS 4085-31-8
PubChem Compound ID
122262
PubChem Substance ID
5950601, 10240000, 15334392, 29302678, 50043136, 57340047, 80274398, 92251569, 103134334, 103261382, 104415414, 117470297, 118048658, 118844030, 125350088, 129349514, 131314023, 135077962, 137123599, 138218944, 139440458, 143493527, 152035592, 152241247, 163653072, 164232665, 164824367, 174006179, 196105912, 198972196, 223701321, 224062913, 226500372, 249614087, 251912304, 251916614, 252411866
Target and Pathway
Target(s) Sarcoplasmic/endoplasmic reticulum calcium ATPase Target Info Inhibitor [536602]
References
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.

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