Drug General Information
Drug ID
D04HEZ
Former ID
DIB018214
Drug Name
[3H](R)-alpha-methylhistamine
Synonyms
(R)-[3H]alpha-methylhistamine; [3H]-R-alpha-Methylhistamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538750]
Structure
Download
2D MOL
Formula
C6H11N3
InChI
InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
InChIKey
XNQIOISZPFVUFG-RXMQYKEDSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [535111]
Histamine H3 receptor Target Info Agonist [535111]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
GPCRs, Class A Rhodopsin-like
References
Ref 538750(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1237).
Ref 535111Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.

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