Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D0U1MN
|
||||
Former ID |
DNC011842
|
||||
Drug Name |
1-Ethyl-4-(2-methoxy-phenyl)-piperazine
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Discovery agent | Investigative | [1] | ||
Structure |
![]() |
Download2D MOL |
|||
Formula |
C13H20N2O
|
||||
Canonical SMILES |
CCN1CCN(CC1)C2=CC=CC=C2OC
|
||||
InChI |
1S/C13H20N2O/c1-3-14-8-10-15(11-9-14)12-6-4-5-7-13(12)16-2/h4-7H,3,8-11H2,1-2H3
|
||||
InChIKey |
VLKJSRWSKNCNBI-UHFFFAOYSA-N
|
||||
PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 1A receptor | Target Info | Inhibitor | [1] | |
5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [1] | ||
KEGG Pathway | cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channels | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway | |||||
Reactome | Serotonin receptors | ||||
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors | |||||
G alpha (q) signalling events | |||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
REF 1 | J Med Chem. 1994 Aug 19;37(17):2754-60.Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.