Drug Information

Drug General Information
Drug ID
D0V8AC
Former ID
DIB020932
Drug Name
SD-208
Synonyms
SCI-208
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543008]
Structure
Download
2D MOL
Formula
C17H10ClFN6
InChI
InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChIKey
BERLXWPRSBJFHO-UHFFFAOYSA-N
PubChem Compound ID
10316032
PubChem Substance ID
15325148, 22687180, 24899731, 29217656, 41381855, 57374546, 75033058, 99453617, 103534840, 104083354, 125767282, 134964519, 135697696, 137275822, 139720427, 152258471, 152344446, 160647306, 162248104, 163685748, 179694512, 186007040, 188376266, 204358201, 223704855, 224283133, 226738899, 241124675, 241376350, 244650250, 249565926, 249617808, 252157146, 252160103, 252480883
Target and Pathway
Target(s) TGF-beta receptor type I Target Info Inhibitor [528660]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
FoxO signaling pathway
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Adherens junction
Chagas disease (American trypanosomiasis)
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
PANTHER Pathway TGF-beta signaling pathway
Pathway Interaction Database Glypican 1 network
ALK1 signaling events
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
TGF-beta receptor signaling
Reactome TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
WikiPathways TGF Beta Signaling Pathway
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Extracellular vesicle-mediated signaling in recipient cells
Cardiac Hypertrophic Response
Signaling by TGF-beta Receptor Complex
Integrated Pancreatic Cancer Pathway
Integrated Breast Cancer Pathway
References
Ref 543008(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8246).
Ref 528660Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1843-9. Epub 2007 Jan 24.

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