Drug Information

Drug General Information
Drug ID
D07YFL
Former ID
DIB019801
Drug Name
EFPPEA
Synonyms
ethyl-furo-pyrazolo-pyridine-ethyl-acetamide; N-[2-(2-Ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)ethyl]acetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542726]
Structure
Download
2D MOL
Formula
C15H19N3O2
InChI
InChI=1S/C15H19N3O2/c1-3-13-11(4-7-16-10(2)19)15-12-6-9-20-14(12)5-8-18(15)17-13/h5,8H,3-4,6-7,9H2,1-2H3,(H,16,19)
InChIKey
IZDHETWMKYCGAU-UHFFFAOYSA-N
PubChem Compound ID
24954989
PubChem Substance ID
56252811, 57484327, 134444345, 136354274, 140517471, 223366107, 224354908, 226494325, 246366079
Target and Pathway
Target(s) Melatonin receptor Target Info Agonist [531472]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 542726(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7774).
Ref 531472Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands. J Med Chem. 2011 Jun 23;54(12):4207-18.

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