Drug Information

Drug General Information
Drug ID
D0XR9Z
Former ID
DIB020911
Drug Name
SB251023
Synonyms
SB-251023
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540406]
Structure
Download
2D MOL
Formula
C28H34NO6P
InChI
InChI=1S/C28H34NO6P/c30-23-10-14-25(15-11-23)34-20-24(31)19-29-28(16-4-5-17-28)18-22-8-12-26(13-9-22)35-21-36(32,33)27-6-2-1-3-7-27/h1-3,6-15,24,29-31H,4-5,16-21H2,(H,32,33)/t24-/m0/s1
InChIKey
MKEFUSOCGOBQMJ-DEOSSOPVSA-N
PubChem Compound ID
9958026
PubChem Substance ID
14933738, 24226792, 46054629, 79923314, 178100462, 231022277, 247083300
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [526315]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540406(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3468).
Ref 526315Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways. Br J Pharmacol. 2002 Apr;135(8):1903-14.

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