Drug General Information
Drug ID	D0J9VP
Former ID	DNC011549
Drug Name	3-tert-Butyl-3-ethyl-dihydro-furan-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533975]
Structure		Download 2D MOL 3D MOL
Formula	C10H18O2
Canonical SMILES	CCC1(CCOC1=O)C(C)(C)C
InChI	1S/C10H18O2/c1-5-10(9(2,3)4)6-7-12-8(10)11/h5-7H2,1-4H3
InChIKey	LHTNJLBXDQITGL-UHFFFAOYSA-N
PubChem Compound ID	10261531
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[533975]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[533975]
	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[533975]
	Gamma-aminobutyric acid receptor subunit beta-2	Target Info	Inhibitor	[533975]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Serotonergic synapse
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 533975	J Med Chem. 1994 Jan 21;37(2):275-86.Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.
Ref 533975	J Med Chem. 1994 Jan 21;37(2):275-86.Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.

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