Drug Information

Drug General Information
Drug ID
D04DYM
Former ID
DIB019979
Drug Name
GW1929
Synonyms
GW 1929; GW-1929
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539763]
Structure
Download
2D MOL
Formula
C30H29N3O4
InChI
InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
InChIKey
QTQMRBZOBKYXCG-MHZLTWQESA-N
PubChem Compound ID
6518171
PubChem Substance ID
10852020, 11111229, 11114172, 11630007, 14761944, 14933109, 17396616, 17405063, 26758839, 43173842, 48319563, 50104927, 50104928, 53777606, 57370860, 75440782, 91704287, 92098558, 92304015, 103391063, 103984531, 104831349, 114621501, 124749763, 129073586, 135262415, 135650330, 141032447, 142718635, 163686321, 163688005, 164042009, 185990415, 198943189, 210280920, 223394013, 223445161, 228734220, 252479048
Target and Pathway
Target(s) mRNA of PPAR-gamma Target Info Agonist [525528]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 539763(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2703).
Ref 525528A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes. 1999 Jul;48(7):1415-24.

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