Drug Information

Drug General Information
Drug ID
D0Y7PG
Former ID
DAP000607
Drug Name
Tolcapone
Synonyms
Tasmar; Roche brand of tolcapone; Ro 40-7592; Tasmar (TN); Tolcapone [USAN:INN]; Ro-40-7592; Tolcapone (JAN/USAN/INN); Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl); (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone; (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone; 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone; 3,4-dihydroxy-5'-methyl-5-nitrobenzophenone
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [536923], [541756]
Therapeutic Class
Antiparkinson Agents
Structure
Download
2D MOL

3D MOL
Formula
C14H11NO5
InChI
InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
InChIKey
MIQPIUSUKVNLNT-UHFFFAOYSA-N
CAS Number
CAS 134308-13-7
PubChem Compound ID
4659569
PubChem Substance ID
10150, 591969, 6867176, 7847851, 7979465, 9606603, 11528675, 12014507, 15221967, 36965801, 46504932, 48416644, 50126317, 53789624, 57357233, 57394327, 77396301, 92308890, 92719235, 93166190, 99452900, 103412696, 104004042, 113211425, 118048594, 124893730, 125728425, 126573748, 126620976, 126653872, 126666929, 126732537, 128601362, 134220789, 134337898, 135029479, 135610139, 137001454, 138121037, 138139359, 144206516, 144212731, 152041747, 160963671, 162110971, 162176782, 163122304, 163621082, 163686405, 164178033
SuperDrug ATC ID
N04BX01
SuperDrug CAS ID
cas=134308137
Target and Pathway
Target(s) Catechol-O-methyl-transferase Target Info Inhibitor [534927], [535173]
BioCyc Pathway L-dopa degradation
Dopamine degradation
Noradrenaline and adrenaline degradation
KEGG Pathway Steroid hormone biosynthesis
Tyrosine metabolism
Metabolic pathways
Dopaminergic synapse
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathway
PathWhiz Pathway Tyrosine Metabolism
WikiPathways Methylation Pathways
Metapathway biotransformation
Estrogen metabolism
Biogenic Amine Synthesis
Dopamine metabolism
Phase II conjugation
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 536923Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
Ref 541756(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6646).
Ref 534927Tolcapone: a novel approach to Parkinson's disease. Am J Health Syst Pharm. 1999 Nov 1;56(21):2195-205.
Ref 535173Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22.

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